★★★★★
Thousands of 5 Star Reviews
★★★★★

Total health is important to me, so PerioSciences is the only toothpaste and mouth rinse I put into my body.

- Erin J.
Austin, TX
★★★★★

HALLELUJAH. PerioSciences is the only product I’ve found that works! No more sensitivity and the canker sores are gone! I’m so thankful!

- Kathy H.
Fredericksburg, TX
★★★★★

Great product! Alcohol free and a great taste. It doesn’t burn your mouth like other mouth rinses.

- Kristin S.
Oklahoma City, OK
★★★★★

Who knew antioxidants were also important for your teeth. This White Care toothpaste really helped get rid of the discoloration on my teeth caused by coffee.

- Chidi Y.
San Jose, CA
★★★★★

I got the gel to use after I had teeth pulled. My gums felt great and it was very soothing. You definitely can’t go wrong using this.

- Becca G.
McAllen, TX
★★★★★

The Sensitive toothpaste is much better than Sensodine. The taste is pleasant and the paste is not chalky.A tube lasts a long time.

- Javier R.
Seattle, WA
★★★★★

Excellent products! They were recommended by my dentist.

- Brittany C.
Bainbridge, WA
★★★★★

The PerioSciences Sensitive Oral Care System actually improved the overall condition of my gums and sensitivity. I’ve been a faithful user twice a day and it offers rouond-the-clock relief.

- Kris F.
Santa Monica, CA

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Why Dentists Trust PerioSciences

With so many oral care options available, it helps to know what dental professionals actually stand behind.

In this video, Dr. Yazzi shares why our antioxidant-powered formulas are designed to support gum health, comfort, and long-term wellness — without harsh ingredients or unnecessary fillers.

Thoughtfully formulated. Professionally trusted.

Our comprehensive approach to oral care
Cavities. Yellowing teeth. Sensitivity. Dry mouth. These are but a few examples of the many issues we experience when it comes to oral care. To help, we’ve worked with the dentist community for 10+ years to develop antioxidant toothpastes that harness the power of natural, plant-based ingredients - to give you powerfully effective oral care solutions. Discover which of our antioxidant toothpastes is right for you
Natural Antioxidant Toothpaste Hydrating Antioxidant Toothpaste Antioxidant Toothpaste For Sensitive Teeth Post-Whitening Antioxidant Toothpaste
Enjoy fresh breath and powerfully effective natural oral care with this toothpaste. It contains no Fluoride, and is free of harsh chemicals like alcohol, sodium lauryl sulfate, parabens, and artificial sweeteners. Delivers a delightfully minty full-mouth refresh. This toothpaste is free of harsh chemicals that dry out your mouth, and packed with botanicals and antioxidants that help keep your mouth clean and fresh. Our comprehensive approach to oral care clinically proven to provide sensitivity relief within 72 hours. And helps clean and repair teeth. So much more than a traditional toothpaste – this is tried, trusted, and recommended by dentists for tackling feelings of sensitivity in your mouth. Specially formulated using a unique blend of citrus extracts and micro-minerals to polish and clean surface stains. This toothpaste will help keep your smile bright and white, while supporting oral health!

NATURAL ANTIOXIDANT TOOTHPASTE

Enjoy fresh breath and powerfully effective natural oral care with this toothpaste. It contains no Fluoride, and is free of harsh chemicals like alcohol, sodium lauryl sulfate, parabens, and artificial sweeteners.

HYDRATING ANTIOXIDANT TOOTHPASTE

Delivers a delightfully minty full-mouth refresh. This toothpaste is free of harsh chemicals that dry out your mouth, and packed with botanicals and antioxidants that help keep your mouth clean and fresh.

ANTIOXIDANT TOOTHPASTE FOR SENSITIVE TEETH

Our comprehensive approach to oral care Clinically proven to provide sensitivity relief within 72 hours. And helps clean and repair teeth. So much more than a traditional toothpaste – this is tried, trusted, and recommended by dentists for tackling feelings of sensitivity in your mouth.

POST-WHITENING ANTIOXIDANT TOOTHPASTE

Specially formulated using a unique blend of citrus extracts and micro-minerals to polish and clean surface stains. This toothpaste will help keep your smile bright and white, while supporting oral health!

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From our Blog

  1. What is a Natural Toothpaste?
    Russell Moon Jun 24, 2025

    What is a Natural Toothpaste?

  2. Harnessing the Power of Antioxidants for Optimal Oral Health
  3. Why Are My Teeth So Yellow? Causes And Treatments
    Russell Moon Oct 28, 2024

    Why Are My Teeth So Yellow? Causes And Treatments

    Teeth naturally have a white-yellow hue to them. This is because the enamel, the protective layer outside your teeth, is white, but can be thinner for some people and even translucent. The layer directly under the enamel is light yellow. Therefore, it is perfectly natural to have a light yellow color on your teeth, and it is not caused by poor oral health.

  4. Why Is My Mouth So Dry When I Wake Up?
    Ericka Simancas Mar 03, 2026

    Why Is My Mouth So Dry When I Wake Up?

    Next to waking up with a numb arm, waking up with a bone dry mouth in the morning can be one of the worst ways to start your day. For some people some simple changes in habit can help prevent dry mouth in the morning, but for others the issue may be more serious. If you are concerned that you’re consistently waking up in the morning with this condition, please contact your doctor immediately.

  5. In What Order Do You Brush, Floss and Use Mouthwash?
    Ericka Simancas Nov 25, 2024

    In What Order Do You Brush, Floss and Use Mouthwash?

    When you brush your teeth using a fluoride toothpaste, you are actively getting rid of food particles and dental plaque (sticky yellowish-white film that forms on your teeth after eating a meal).

  6. What Does A Cavity Look Like? (And Does It Hurt?)
  7. Does Hydroxyapatite Toothpaste Work?
    John Kelly Mar 28, 2024

    Does Hydroxyapatite Toothpaste Work?

    Before we dive into Hydroxyapatite Toothpaste and answer the question; Does hydroxyapatite toothpaste work? Let's take a look at hydroxyapatite itself.

  8. Foods That Strengthen Teeth (And Foods To Avoid)

Frequently Asked Questions

+ What are antioxidant toothpastes?

Antioxidant toothpastes are toothpastes made from antioxidants and naturally sourced ingredients considered to be effective in promoting good oral care. For example, we combine dentist-trusted ingredients with antibacterial properties along with a unique blend of phloretin and ferulic acid alongside other plant-based ingredients to freshen your breath and soothe your mouth’s sensitive soft tissue. We worked with the dentist community for over a decade to develop our patented formula, and we’re confident it provides powerful results. But don’t just take our word for it – visit our reviews page and read what dentists and people across the world have to say about our antioxidant toothpastes!

+ Are antioxidants good for teeth?

Studies show that low antioxidant levels in saliva are strongly correlated with many oral diseases. Topically adding antioxidants on a daily basis to saliva allows the additional support to work in concert with your body's natural defense system. The addition of antioxidants to your daily oral care regime promotes good oral health. Learn what foods are good for your teeth.

Which antioxidant toothpaste is right for me?

This will depend on your oral health goals, or the dental issue you are facing. Our Toothpaste for Sensitive Teeth is clinically proven to help reduce severe cases of sensitivity within 72 hours. If you experience dry mouth, then choose our Hydrating Toothpaste. It's formulated with moisturizers to support saliva flow and provide a hydrated, fresh feeling. Our Post-Whitening Toothpaste extends the effects of professional whitening treatments. And if you want a natural, fluoride-free toothpaste that uses plant-based agents to protect your teeth, then choose our Natural Toothpaste. Having trouble deciding? Take our Smile Care quiz to find the right toothpaste for you.

Are your antioxidant toothpastes fluoride-free?

AO ProToothpaste Natural is Fluoride-free. Our White Care, Sensitive, and Hydrating formulas contain Fluoride and Nano-Hydroxyapatite to strengthen teeth and fight cavities.

Why is Hydroxyapatite a key ingredient, and how does it support my enamel?

Hydroxyapatite is the main mineral component of your natural dental enamel and dentin. Our toothpastes use a precise combination of Hydroxyapatite and silica to provide superior yet gentle cleaning that avoids enamel erosion. Dental research has shown that Hydroxyapatite is able to remineralize subsurface areas of demineralized enamel and can reduce dental sensitivity, especially following bleaching procedures.

Do your toothpastes contain alcohol, parabens, SLS or artificial sweeteners?

No. All of our toothpastes are free from harsh chemicals.

Are these toothpastes safe for use with veneers, crowns, or dental appliances?

Yes. Our toothpastes are specially formulated to help lift surface stains without being harsh on your teeth. We use a gentle, advanced ingredient called Plasdone. Think of Plasdone like a microscopic magnet - it works by surrounding and lifting away the stain-causing compounds from things like coffee and tea that stick to your teeth. Plasdone is non-abrasive and cleans your teeth without scratching or wearing down your enamel, making it ideal for sensitive teeth and for maintaining the look of crowns, veneers, and other specialized dental work. Basically, you get a brighter smile through a gentle lifting action rather than a harsh scrubbing or bleaching process.

How long will one tube of toothpaste last?

Each 3 oz tube of AO ProToothpaste is designed to last for approximately 60 days of use when brushing twice daily.

How do I use your antioxidant toothpastes?

Apply the toothpaste onto a soft bristled toothbrush. Brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or doctor. For best results, pair with a mouth rinse and our dental gel.

Can I use your antioxidant toothpastes alongside other PerioSciences oral care products?

Yes, they are designed to be used as part of a complete oral hygiene regimen. For comprehensive care and best results, consider our Oral Care Systems.