Collection: Antioxidant Toothpastes

Enjoy a full mouth refresh with our antioxidant toothpastes. Free from harsh chemicals and great for your teeth and gums, they're made from a combination of ingredients with both antibacterial and antioxidant properties to provide a natural, novel approach to oral care. What’s more, our antioxidant-based products are used and recommended by over a thousand dentists nationally! Premium formula, powerful results. If you're looking for a specialized option, our periodontist toothpaste is designed to meet the needs of gum health and provide targeted care for your oral hygiene.

Collection: Antioxidant Toothpastes

A unique science-backed approach to oral care

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Our comprehensive approach to oral care
Cavities. Yellowing teeth. Sensitivity. Dry mouth. These are but a few examples of the many issues we experience when it comes to oral care. To help, we’ve worked with the dentist community for 10+ years to develop antioxidant toothpastes that harness the power of natural, plant-based ingredients - to give you powerfully effective oral care solutions. Discover which of our antioxidant toothpastes is right for you
Natural Antioxidant Toothpaste Hydrating Antioxidant Toothpaste Antioxidant Toothpaste For Sensitive Teeth Post-Whitening Antioxidant Toothpaste
Enjoy fresh breath and powerfully effective natural oral care with this toothpaste. It contains no Fluoride, and is free of harsh chemicals like alcohol, sodium lauryl sulfate, parabens, and artificial sweeteners. Delivers a delightfully minty full-mouth refresh. This toothpaste is free of harsh chemicals that dry out your mouth, and packed with botanicals and antioxidants that help keep your mouth clean and fresh. Our comprehensive approach to oral care clinically proven to provide sensitivity relief within 72 hours. And helps clean and repair teeth. So much more than a traditional toothpaste – this is tried, trusted, and recommended by dentists for tackling feelings of sensitivity in your mouth. Specially formulated using a unique blend of citrus extracts and micro-minerals to polish and clean surface stains. This toothpaste will help keep your smile bright and white, while supporting oral health!

NATURAL ANTIOXIDANT TOOTHPASTE

Enjoy fresh breath and powerfully effective natural oral care with this toothpaste. It contains no Fluoride, and is free of harsh chemicals like alcohol, sodium lauryl sulfate, parabens, and artificial sweeteners.

HYDRATING ANTIOXIDANT TOOTHPASTE

Delivers a delightfully minty full-mouth refresh. This toothpaste is free of harsh chemicals that dry out your mouth, and packed with botanicals and antioxidants that help keep your mouth clean and fresh.

ANTIOXIDANT TOOTHPASTE FOR SENSITIVE TEETH

Our comprehensive approach to oral care Clinically proven to provide sensitivity relief within 72 hours. And helps clean and repair teeth. So much more than a traditional toothpaste – this is tried, trusted, and recommended by dentists for tackling feelings of sensitivity in your mouth.

POST-WHITENING ANTIOXIDANT TOOTHPASTE

Specially formulated using a unique blend of citrus extracts and micro-minerals to polish and clean surface stains. This toothpaste will help keep your smile bright and white, while supporting oral health!

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Take It From The Pros

  • Dr. M. Crofcheck
    quote

    "I conduct many periodontal procedures each year. I recommend the PerioSciences products to all my patients as an important component of their home care regimen."

    - Dr. M. Crofcheck

    Periodontist

    Houston, TX

  • Dr. S. John
    quote

    "Our post-op patients need time to heal and a good after care regimen. When they use AO ProVantage, their soft tissues instantly feel soothed/quickly feel much better."

    - Dr. S. John

    Periodontist

    San Mateo, CA

  • Dr. J. Kim
    quote

    "The use of antioxidants to enhance and accelerate healing immediately after surgery is a new standard of care."

    - Dr. J. Kim

    Periodontist

    Diamond Bar, CA

  • quote

    "I have recommended the AO Gel to my post-surgical patients for more than 5 years. Patients love the refreshing soothing effects when they use it as part of their home care/after care oral hygiene regimen."

    - Dr. E. Allen

    Periodontist

    Dallas, TX

  • quote

    "PerioSciences is a part of my patients post-surgical protocol. All patients, even the healthiest ones, benefit from the soothing properties of PerioSciences gel, no matter what the condition."

    - Dr. D. Yu

    Periodontist

    Austin, TX

  • quote

    "Topically applied antioxidants in AO ProVantage gel are known for their anti-inflammatory effects.* It is my go-to recommendation to support patient's healing after all periodontal procedures." *shown in laboratory studies

    - Dr. S. Low

    Periodontist

    Gainesville, FL

From our Blog

  1. What is a Natural Toothpaste?
    Russell Moon Jun 24, 2025

    What is a Natural Toothpaste?

  2. Harnessing the Power of Antioxidants for Optimal Oral Health
  3. Why Are My Teeth So Yellow? Causes And Treatments
    Russell Moon Oct 28, 2024

    Why Are My Teeth So Yellow? Causes And Treatments

    Teeth naturally have a white-yellow hue to them. This is because the enamel, the protective layer outside your teeth, is white, but can be thinner for some people and even translucent. The layer directly under the enamel is light yellow. Therefore, it is perfectly natural to have a light yellow color on your teeth, and it is not caused by poor oral health.

  4. Why Is My Mouth So Dry When I Wake Up?
    Ericka Simancas May 24, 2025

    Why Is My Mouth So Dry When I Wake Up?

    Next to waking up with a numb arm, waking up with a bone dry mouth in the morning can be one of the worst ways to start your day. For some people some simple changes in habit can help prevent dry mouth in the morning, but for others the issue may be more serious. If you are concerned that you’re consistently waking up in the morning with this condition, please contact your doctor immediately.

  5. In What Order Do You Brush, Floss and Use Mouthwash?
    Ericka Simancas Nov 25, 2024

    In What Order Do You Brush, Floss and Use Mouthwash?

    When you brush your teeth using a fluoride toothpaste, you are actively getting rid of food particles and dental plaque (sticky yellowish-white film that forms on your teeth after eating a meal).

  6. What Does A Cavity Look Like? (And Does It Hurt?)
  7. Does Hydroxyapatite Toothpaste Work?
    John Kelly Mar 28, 2024

    Does Hydroxyapatite Toothpaste Work?

    Before we dive into Hydroxyapatite Toothpaste and answer the question; Does hydroxyapatite toothpaste work? Let's take a look at hydroxyapatite itself.

  8. Foods That Strengthen Teeth (And Foods To Avoid)

FAQs

Antioxidant toothpastes are toothpastes made from antioxidants and naturally sourced ingredients considered to be effective in promoting good oral care. For example, we combine dentist-trusted ingredients with antibacterial properties along with a unique blend of phloretin and ferulic acid alongside other plant-based ingredients to freshen your breath and soothe your mouth’s sensitive soft tissue. We worked with the dentist community for over a decade to develop our patented formula, and we’re confident it provides powerful results. But don’t just take our word for it – visit our reviews page and read what dentists and people across the world have to say about our antioxidant toothpastes!

Studies show that low antioxidant levels in saliva are strongly correlated with many oral diseases. Topically adding antioxidants on a daily basis to saliva allows the additional support to work in concert with your body's natural defense system. The addition of antioxidants to your daily oral care regime promotes good oral health. Learn what foods are good for your teeth.

This will depend on your oral health goals, or the dental issue you are facing. Our Toothpaste for Sensitive Teeth is clinically proven to help reduce severe cases of sensitivity within 72 hours. If you experience dry mouth, then choose our Hydrating Toothpaste. It's formulated with moisturizers to support saliva flow and provide a hydrated, fresh feeling. Our Post-Whitening Toothpaste extends the effects of professional whitening treatments. And if you want a natural, fluoride-free toothpaste that uses plant-based agents to protect your teeth, then choose our Natural Toothpaste. Having trouble deciding? Take our Smile Care quiz to find the right toothpaste for you.

AO ProToothpaste Natural is Fluoride-free. Our White Care, Sensitive, and Hydrating formulas contain Fluoride and Nano-Hydroxyapatite to strengthen teeth and fight cavities.

Hydroxyapatite is the main mineral component of your natural dental enamel and dentin. Our toothpastes use a precise combination of Hydroxyapatite and silica to provide superior yet gentle cleaning that avoids enamel erosion. Dental research has shown that Hydroxyapatite is able to remineralize subsurface areas of demineralized enamel and can reduce dental sensitivity, especially following bleaching procedures.

No. All of our toothpastes are free from harsh chemicals.

Yes. Our toothpastes are specially formulated to help lift surface stains without being harsh on your teeth. We use a gentle, advanced ingredient called Plasdone. Think of Plasdone like a microscopic magnet - it works by surrounding and lifting away the stain-causing compounds from things like coffee and tea that stick to your teeth. Plasdone is non-abrasive and cleans your teeth without scratching or wearing down your enamel, making it ideal for sensitive teeth and for maintaining the look of crowns, veneers, and other specialized dental work. Basically, you get a brighter smile through a gentle lifting action rather than a harsh scrubbing or bleaching process.

Each 3 oz tube of AO ProToothpaste is designed to last for approximately 60 days of use when brushing twice daily.

Apply the toothpaste onto a soft bristled toothbrush. Brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or doctor. For best results, pair with a mouth rinse and our dental gel.

Yes, they are designed to be used as part of a complete oral hygiene regimen. For comprehensive care and best results, consider our Oral Care Systems.