The toothpaste dentists
recommend for seriously sensitive teeth

Trusted by experts: recommended by 2600+ dentists

Rapid relief: clinically proven to reduce sensitivity in 72 hours

Long-lasting relief: specially formulated to remineralize teeth

What the experts say

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"We get remarkable results within 72 hours of patient use [...] a quality solution to tooth sensitivity."

Dr Sam Low

Specialist Periodontist

Gainesville, Florida

"[For] challenging cases, my go-to recommendation is PerioSciences Toothpaste for Sensitive Teeth."

Gretchen Estep

Registered Dental

Plano, Texas

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Sensitivity relief like no other

Recommended by dentists

For over 10 years, we’ve worked with the dentist community to develop our antioxidant toothpastes. They’re so effective they’re recommended by 2600+ dentists in the US.

Specially formulated
oral care

A unique blend of ingredients including natural antioxidants, Potassium Nitrate, Sodium Monoflurophosphate, and Nano-Hydroxyapatite combine to help remineralize teeth and give you long-lasting relief from sensitivity.

Includes special ingredient

In the field of dental research, Nano-Hydroxyapatite is shown to help remineralize enamel, reduce sensitivity post whitening, and improve tooth color.

Helping you discover your best smile

  • Really helps w/ sensitive teeth

    I started using this toothpaste several years ago, and it has really helped to decrease the sensitivity of my teeth. I used to have a very hard time with anything cold in my mouth, but now it doesn't bother me at all! This product is expensive, but I just use a small amount, and it lasts a really long time [...].

    Kia J.

    Verified Buyer

  • Works!

    I have awfully sensitive teeth to start with and then I recently had oral surgery and couldn’t even stand the idea of brushing those teeth again. It was brutal. I bought this product and it worked the first try it was almost painless. I’m so pleased.

    Joan Marie McCully

    Verified Buyer

  • Great healing and soothing effects!

    This product has given me great relief from very sensitive gums and also a condition that causes my inside cheeks to be very painful and raw. I dreaded brushing my teeth because of the associated pain until I found this product. Now, I can brush three times a day without discomfort.

    Jules H.

    Verified Buyer

  • Can't live without it

    I have a lot of gum sensitivity. Before I found out about this toothpaste I had a very difficult time eating and drinking. My dentist told me about PerioSciences and my pain level went way down. This is the only toothpaste I use now.

    Gary M.

    Verified Buyer

  • Five stars

    I was looking for a toothpaste without harsh chemicals and my dentist recommended PerioSciences. I have been using it for a couple of years now and love it. No bad aftertaste and my teeth and gums are doing great. Even my tooth sensitivity has disappeared.

    Sandy Schaut

    Verified Buyer

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Toothpaste For Sensitive Teeth

Clinically proven relief within 72 hours

Recommended by 2600+ dentists

Formulated for long-lasting relief

Contains Nano-Hydroxyapatite


Mint flavored

Made in the USA

Lasts 60 days

$0.16 per use

Don't let tooth sensitivity keep you from eating, drinking, and doing the things you love. Try our specially formulated AO Pro Toothpaste for Sensitive Teeth.



PerioSciences Toothpaste for Sensitive Teeth is for adults and children 12 years and older. Simply squeeze the toothpaste onto a soft bristled toothbrush, and then brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or doctor.

For best results, use with PerioSciences Mouthwash for Sensitive Teeth and AO ProVantage Gel.

When used as suggested, our Toothpaste for Sensitive Teeth should last for 60 days (or approximately $0.16 per use).

Soothing ingredients

Our Toothpaste for Sensitive Teeth has been specially formulated by our team of dental experts and scientists.

It contains the maximum amount of Fluoride allowed for over-the-counter toothpastes, along with a unique blend of naturally occurring minerals, including Potassium Nitrate that works to reduce tooth sensitivity within 72 hours.

Furthermore, we’ve borrowed brilliance from advanced skincare to enhance your oral health. Allantoin is known for its anti-irritation properties, while Phloretin and Ferulic Acid bring game-changing antioxidant protection to your daily oral care.

What makes our toothpaste truly special is not just the ingredients but their unique combination that combats sensitivity and gently cleans and strengthens teeth.

Learn more about the key ingredients below.

Toothpastes for every need

Do you want to clean your mouth using a toothpaste that contains only natural, fluoride-free ingredients?


Mouth as dry as a desert? Do you need a toothpaste that cleans your teeth and leaves a pleasant, hydrated feeling in your mouth?


Sensitivity keeping you from enjoying your favorite foods and drinks? Looking for a clinically proven solution recommended by dentists?

White Care

Want a brighter, healthier smile? Do you want to maintain and even enhance whitening treatments while soothing your gums?

Frequently Asked Questions